Rare coding variation and risk for myocardial infarction

项目来源

美(略)和(略)务(略)((略))

项目主持人

C(略)S(略) (略)W(略)

项目受资助机构

W(略)I(略)O(略)N(略)R(略)Y

立项年度

2(略)

立项时间

未(略)

项目编号

5(略)H(略)4(略)-(略)

项目级别

国(略)

研究期限

未(略) (略)

受资助金额

1(略)6(略)0(略)

学科

C(略)i(略)s(略)a(略)C(略)i(略) (略)e(略)h(略)e(略)i(略) (略)r(略)i(略)s(略)H(略)t(略)s(略)e(略)C(略)n(略) (略)r(略)i(略)s(略)H(略)n(略)n(略);(略)e(略)t(略);

学科代码

未(略)

基金类别

O(略)r(略)s(略)c(略)e(略)e(略)

关键词

未(略)

参与者

S(略)Z(略),(略)T(略) (略)V(略)

参与机构

N(略)O(略) (略)R(略)L(略),(略)D(略)O(略)I(略)I(略)E

项目标书摘要:DE(略)provided (略)t): Myoca(略)ction (MI(略)ading cau(略) in the U(略)s and is (略)Large stu(略)ng on com(略) variatio(略)identifie(略)oci assoc(略)risk for (略) this suc(略) common v(略)lain only(略)oportion (略)tic basis(略)ulation g(略) candidat(略)ies suppo(略)thesis th(略)mon genet(略)n plays a(略)t role in(略)sorders s(略)In this p(略) outline (略)hods to e(略)role of r(略) variatio(略)or MI. Us(略)f rare (m(略) frequecy(略)ng varian(略)ed throug(略)me sequen(略)all prote(略)egions of(略)), we wil(略)hypothese(略) variants(略) to MI ri(略)ividually(略)tively an(略)hat this (略)an improv(略)n-based r(略)ication. (略)se hypoth(略)opose the(略)specific (略)m 1, we w(略)e exome v(略)a well-po(略)control s(略)ntify rar(略)that indi(略)ntribute (略)MI; in Ai(略)l develop(略)utational(略)r rare va(略)sis to id(略) variants(略)ly associ(略)I; and in(略)will deve(略)variant m(略)opulation(略)isk strat(略)In additi(略)dating th(略)are codin(略) in risk (略)s five-ye(略) outlines(略)nsive str(略)he princi(略)gator's c(略)opment in(略)ardiovasc(略)ne. This (略)gically b(略)e princip(略)ator's pr(略)arch expe(略)clinical (略)fter obta(略)D. in Bio(略), the pri(略)stigator (略)esidency (略) Internal(略)nd is cur(略)shing fel(略)ining in (略)lar Disea(略)oposal no(略)n expandi(略)ntific sk(略)aining ad(略)owledge a(略)l researc(略)e in huma(略)and genom(略)tical gen(略)risk mode(略)areer dev(略)als will (略) through (略)eted appr(略)ing mento(略) Sekar Ka(略)uman gene(略)nomics) a(略)il Sunyae(略)cal genet(略)odeling),(略)oursework(略)c investi(略) training(略)fic commu(略)d researc(略)his work (略)lace in a(略)ining env(略)mprised o(略)tary expe(略)Massachus(略)l Hospita(略)and Women(略), and the(略)itute. Su(略)mpletion (略)eer devel(略)d will re(略)etter und(略)of the ge(略) for MI, (略)he princi(略)gator' tr(略) an indep(略)ician-sci(略) provide (略)ndation f(略)e will ap(略)-level fu(略)

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