Complement and Pathogenic Mechanisms of AMD

项目来源

美(略)和(略)务(略)((略))

项目主持人

S(略),(略)A(略)L

项目受资助机构

D(略) (略)V(略)I(略)

立项年度

2(略)

立项时间

未(略)

项目编号

3(略)E(略)9(略)-(略)1

项目级别

国(略)

研究期限

未(略) (略)

受资助金额

9(略).(略)元

学科

A(略)g(略)l(略)i(略)'(略)i(略)s(略)B(略)n(略)s(略)e(略) (略)e(略)a(略)y(略)i(略)s(略)n(略)i(略)d(略) (略)V(略)o(略)G(略)t(略);(略)c(略)r(略)g(略)r(略)o(略)N(略)o(略)e(略)a(略)e(略)

学科代码

未(略)

基金类别

N(略)S(略)/(略)R(略)G(略)

关键词

未(略)

参与者

B(略)S(略)C(略)N(略)A(略)R(略)

参与机构

N(略)O(略) (略) (略)T(略)T(略)

项目标书摘要:DE(略)provided (略)t): Age-r(略)lar degen(略)D) is a l(略)e of visu(略)ion world(略) characte(略)e accumul(略)tracellul(略)nd protei(略)g deposit(略)he retina(略)pithelium(略)Bruch's m(略)M). These(略)posits ma(略)(drusen) (略)and are l(略)ntribute (略)pathogene(略)gression (略)ed for ex(略) deposits(略)lify othe(略)such as A(略)disease. (略)e molecul(略) these di(略)be divers(略)thogenic (略)ntain man(略)nstituent(略)attributa(略)t, to loc(略)tion and (略)of the co(略)scade. Th(略)omplement(略)hogenesis(略)ed by stu(略)fying com(略)teins in (略)studies i(略)variation(略)mplement (略)FH) gene (略)ngest gen(略) associat(略) risk. Th(略)d risk of(略)ts suppor(略)thesis th(略)flammatio(略)ation of (略)ent casca(略)tes to AM(略)sis. The (略)ns of the(略)rphism on(略) compleme(略)as it per(略)e mainten(略) health o(略)are not y(略)erstood a(略) likely t(略)riggers, (略)and/or me(略)t in conc(略)H in disr(略)delicate (略) of the c(略)ystem. Pr(略)ng these (略)beta (A?)(略)uent of s(略)sits, whi(略)wn activa(略)complemen(略)e hypothe(略)ysregulat(略)nt activi(略)he RPE/Br(略)ontribute(略)mage, sub(略)t formati(略)progressi(略)n this re(略)butes to (略)system dy(略). In supp(略) hypothes(略)ed that A(略)le therap(略)t in the (略)f AMD. Fo(略)nt study,(略)veloped t(略)mouse mod(略)ine the r(略)lement in(略)pment of (略) first tw(略)mplement (略)is suppre(略)mented, r(略), in an e(略)AMD mouse(略)s 1 and 2(略)hird is a(略)zed CFH m(略)sing eith(略)al or AMD(略)of CFH (A(略) model ha(略)nt capaci(略)ulate act(略)lement co(略) the eye (略)s a spect(略)lement de(略)d complem(略) phenotyp(略)rogate th(略)FH in AMD(略)

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